What is IDx Lung?

The Lung IDx Program has a primary focus on early lung cancer detection. The program captures patients from the Lung Screening Program, patients under evaluation for incidentally-detected lung nodules, and patients who undergo percutaneous lung biopsy for an indeterminate lung nodule.


Patients enrolled into the database are followed to tissue diagnosis. In patients with lung cancer diagnoses, first line treatments are captured. The program is supported by a number of extramurally funded grants and contracts.

Research Supported

The Lung IDx Program has centered on the characterization of lung nodules to distinguish benign from malignant lesions as well as to better characterize and predict the biological behavior of early lung cancers, with the goals of expediting early diagnosis and informing management strategies designed to reduce mortality and prolong survival in those with the diagnosis of lung cancer.

Data Sources and Data Types

Lung IDx captures detailed sociodemographic, medical, medical imaging, and digital pathology imaging sources, including detailed risk questionnaires for lung cancer. Beyond histologic and mutational analyses, additional readily accessible biospecimens may be collected in these consented patients, including saliva samples, blood samples for DNA mutations and DNA hypermethylation signatures, and nasal epithelial specimens.


The graphs below give a snapshot of what is in the database and available through the Data Request Process. Graphs are updated on a quarterly basis. IDx Lung consists of three cohorts: lung screening cohort (all screen-eligible cases who have undergone a low-dose CT scan; data entry is prioritized for cases given a LungRADS assessment of 3 or 4), eversmoker cohort (≥ 50 yrs, current/former smoker with a prior identified nodule 6-27 mm and underwent an image-guided biopsy), and biobank cohort (all other cases not included in the eversmoker cohort and underwent an image-guided biopsy). Tissue samples are only available from the biobank and eversmoker cohorts.
Lung Graph 1
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