UCLA Health
Overview
The Integrated Diagnostics Shared Resource generates, maintains, and facilitates access to longitudinal, highly curated radiology-pathology data linked to clinical, molecular, and outcomes information. Our purpose is to catalyze innovative research towards improving the imaging-based detection, diagnosis, and treatment of cancer and advancing our understanding of the tumor microenvironment.
Our vision is to serve as a unique institutional resource that delivers integrated, multi-scale, multi-modal data in a transparent and timely manner.
Our Mission
Catalyze innovative research and tool development through data integration and curation to improve early detection, diagnosis and treatment of cancer.
- Acquire high resolution, spatially registered radiology and pathology images.
- Capture high value clinical and outcomes data.
- Track and annotate findings across all observations at the lesion level.
- Collect biospecimens (blood, tissue) for genomic analysis.
Explore
Functions of the Shared Resource
Regulatory and Oversight
The Research Operations team oversees prospective consenting of participants, manage institutional review board protocols, and serve as an honest broker for data access.
Database and Integration
The Infrastructure team develops and maintains the database, data entry interface, dashboard, integration services, and analytics services.
Image Archiving and Annotations
The Image Archiving & Annotations team is responsible for the banking, deidentification, and annotation of radiological images for each domain.
Data Management
The Data Management team oversees data quality control activities and fulfillment of data access requests.
Type of Data Available
- Clinical and demographical information
- Radiological imaging (e.g., MRI, CT, Ultrasound)
- Digital pathology images
- Image annotations (e.g., organ and lesion segmentation)
- Expert-provided image interpretations (e.g., semantic features)
- Measurements derived from images (e.g., radiomic features)
- Outcomes information (e.g., disease-free survival)
Domains
Prostate
- Matched MRI and whole mount resection cases
- Ex vivo imaging (a subset of resection cases)
- Prospective MR-guided biopsy cohort
Lung
- Lung cancer screening cases
(Lung-RADS 3 & 4) - Prospective CT-guided biopsy with
6-27 mm nodules
Kidney
- Prospective biopsy cohort with prior contrast enhanced CT scans
- CT and/or MRI cases with radiology pathology correlation
Breast
- Prospective ultrasound-guided biopsy cohort with prior tomosynthesis or breast MRI scan
Liver
- US/US Contrast/CT/MRI of Hepatocellular Carcinoma/Hepatic Adenoma with pathology correlation (biopsy and/or resection)