Overview

The Integrated Diagnostics Shared Resource generates, maintains, and facilitates access to longitudinal, highly curated radiology-pathology data linked to clinical, molecular, and outcomes information. Our purpose is to catalyze innovative research towards improving the imaging-based detection, diagnosis, and treatment of cancer and advancing our understanding of the tumor microenvironment.

Our vision is to serve as a unique institutional resource that delivers integrated, multi-scale, multi-modal data in a transparent and timely manner.

Our Mission

Catalyze innovative research and tool development through data integration and curation to improve early detection, diagnosis and treatment of cancer.

Acquire high resolution, spatially registered radiology and pathology images.
Capture high value clinical and outcomes data.
Track and annotate findings across all observations at the lesion level.
Collect biospecimens (blood, tissue) for genomic analysis.

EXPLORE

FUNCTIONS OF THE SHARED RESOURCE

REGULATORY & OVERSIGHT

The Research Operations team oversees prospective consenting of participants, manage institutional review board protocols, and serve as an honest broker for data access.

DATABASE & INTEGRATION

The Infrastructure team develops and maintains the database, data entry interface, dashboard, integration services, and analytics services.

IMAGE ARCHIVING & ANNOTATIONS

The Image Archiving & Annotations team is responsible for the banking, deidentification, and annotation of radiological images for each domain.

DATA MANAGEMENT

The Data Management team oversees data quality control activities and fulfillment of data access requests.

TYPES OF DATA AVAILABLE

Clinical and demographical information
Radiological imaging (e.g., MRI, CT, Ultrasound)
Digital pathology images
Image annotations (e.g., organ and lesion segmentation)
Expert-provided image interpretations (e.g., semantic features)
Measurements derived from images (e.g., radiomic features)
Outcomes information (e.g., disease-free survival)

DOMAINS

PROSTATE

Matched MRI and whole mount resection cases

Ex vivo imaging (a subset of resection cases)

Prospective MR-guided biopsy cohort

LUNG

Lung cancer screening cases
(Lung-RADS 3 & 4)

Prospective CT-guided biopsy with
6-27 mm nodules

KIDNEY

Prospective biopsy cohort with prior contrast enhanced CT scans

CT and/or MRI cases with radiology pathology correlation

BREAST

Prospective ultrasound-guided biopsy cohort with prior tomosynthesis or breast MRI scan

LIVER

US/US Contrast/CT/MRI of Hepatocellular Carcinoma/Hepatic Adenoma with pathology correlation (biopsy and/or resection)